Dang Nguyen, Ph.D.
2019 Funding recipient
Uncovering molecular functions of ATR in Myelodysplastic Syndromes
EvansMDS Young Investigator Award
The EvansMDS Young Investigator Award will provide me with critical funding for the completion of my proposed research and career development. As I transition to become an independent Principle Investigator, I will continue to determine mechanisms in DNA damage response and to translate my findings into the clinic. Since existing therapies for MDS are still inadequate, our pre-clinical evidence represents a promising therapeutic avenue to exploit the R-loop-associated vulnerability driven by spliceosome mutations in MDS patients. Results obtained from my proposal will not only further our basic understanding of R-loop regulation in MDS, but also provide new therapeutic strategies to treat MDS patients. My overall goal is to develop an “R -loop signature” for the purpose of diagnostic and therapeutic monitoring in MDS patients.